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pentobarbital will lessen the extent or effect of saxagliptin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Mysterious.Contraindicated (1)pentobarbital will decrease the level or effect of cariprazine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is liable for the formation and eli